Health economics can feel a bit like alphabet soup — QALYs, ICERs, BIAs… To help you navigate the essentials, CELforPharma faculty member Prof Dr Lieven Annemans, expert-trainer of the courses Health Economics for Non-Health-Economists, Online Self-Study Programme: Basics of Health Economics and Critical New HTA Developments in Europe: Challenges & Solutions, has made a glossary of commonly used terms in health economic evaluations.
A structured comparison of the costs and health effects of alternative healthcare interventions, mostly a new technology or medicine versus Standard of Care (SoC). Helps decision makers judge whether a new technology/medicine provides value for money versus the comparator.
A measure that combines length of life and quality of life into a single index.
The additional cost per additional unit of health gained (often per QALY).
💡 Formula: ICER = (Cost New – Cost SoC ) / (QALYs New – QALYs SoC ) |
The higher the ICER, the less cost-effective a new programme (technology/medicine).
If the ICER is below a country’s threshold for willingness-to-pay for QALY, the new intervention may be considered cost-effective.
The most applied type of health economic evaluations, comparing interventions in terms of cost per unit of health outcome (e.g., cost per QALY gained, cost per life-year saved). Note that, when the health outcomes are expressed in QALYs, several authors prefer the term cost-utility analysis.
An analysis estimating the financial consequences of adopting a new healthcare intervention, usually over a short horizon (3-5 years). Focused on affordability, not cost-effectiveness. The concerned budget can be a narrow pharma or MedTech budget, but also – and better – the broader healthcare budget accounting for offsets in other parts of the system.
The viewpoint taken in an economic study:
A simple economic model using branches to represent possible events and outcomes (e.g. treatment success/failure). Often used for acute diseases without long-term sequelae.
A model that simulates patient transitions between health states (e.g., healthy, sick, dead) over time. Useful for chronic diseases and long-term outcomes.
A more complex model that simulates individual patient journeys and events over time, capturing heterogeneity and complex disease pathways.
Adjusting future costs and health benefits to their present value, reflecting time preference. Typically, a discount rate of ~3% is applied, but differences between countries exist.
Arrangements between manufacturers and payers to allow access to a new therapy under certain conditions (e.g., outcome-based reimbursement, price-volume agreements) to manage uncertainty and affordability.
A forward-looking “value blueprint” outlining what attributes (effectiveness, safety, cost, price) a product should demonstrate to be reimbursed.
Testing how results of health economic evaluations change when assumptions or inputs vary.